1AY6

THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF

1AY6 の概要

• エントリーDOI: 10.2210/pdb1ay6/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000410
• 分子名称: THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUGEN, ... (5 entities in total)
• 機能のキーワード: complex of serine protease-inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P01050
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36098.17

構造登録者

Ganesh, V.,Maryanoff, B.E.,Tulinsky, A. (登録日: 1997-11-14, 公開日: 1998-03-18, 最終更新日: 2023-08-02)

• 主引用文献: Greco, M.N.,Powell, E.T.,Hecker, L.R.,Andrade-Gordon, P.,Kauffman, J.A.,Lewis, J.M.,Ganesh, V.,Tulinsky, A.,Maryanoff, B.E.; Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif; Bioorg.Med.Chem.Lett., 6:2947-2952, 1996; PubMed: 8367461; DOI: 10.1016/S0960-894X(96)00554-9

実験手法

X-RAY DIFFRACTION (1.8 Å)