1AXW

E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)

Summary for 1AXW

• Entry DOI: 10.2210/pdb1axw/pdb
• Descriptor: THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE, ... (4 entities in total)
• Functional Keywords: methyltransferase, transferase, inhibitor
• Biological source: Escherichia coli
• Cellular location: Cytoplasm: P0A884
• Total number of polymer chains: 2
• Total formula weight: 62612.57

Authors

Stout, T.J.,Sage, C.R.,Stroud, R.M. (deposition date: 1997-10-23, release date: 1998-10-28, Last modification date: 2023-08-02)

• Primary citation: Welch, W.,Sage, C.R.,Stout, T.J.,Klein, T.,Ruppert, J.,Stroud, R.M.,Jain, A.; Discovery of Thymidylate Synthase Inhibitors Using Flexible Docking and an Empirically Tuned Scoring Function; To be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)