1AXN

THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V

1AXN の概要

• エントリーDOI: 10.2210/pdb1axn/pdb
• 分子名称: ANNEXIN III, CALCIUM ION (3 entities in total)
• 機能のキーワード: annexin family, calcium-phospholipid-binding protein complex, calcium/phospholipid-binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36583.54

構造登録者

Favier-Perron, B.,Lewit-Bentley, A.,Russo-Marie, F. (登録日: 1995-08-21, 公開日: 1996-03-08, 最終更新日: 2024-02-07)

主引用文献

Favier-Perron, B.,Lewit-Bentley, A.,Russo-Marie, F.
The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.
Biochemistry, 35:1740-1744, 1996

PubMed Abstract: The structure of recombinant human annexin III was solved to 1.8 A resolution. Though homologous to annexin I and V, the annexin III structure shows significant differences. The tryptophan in the calcium loop of the third domain is exposed to the solvent, as in the structure of annexin V crystallized in high calcium concentrations, although the annexin III crystals were prepared at low calcium concentrations. The position of domain III relative to the other domains is different from both annexin V and I, suggesting further flexibility of the molecule. The entire N-terminus of the protein is well-defined in the present structure. The side chain of tryptophan 5 interacts with the hinge region of the hydrophillic channel, which could have an effect on the potential mobility of this region, as well as on its possible calcium channel behavior.

PubMed: 8639653
DOI: 10.1021/bi952092o

実験手法

X-RAY DIFFRACTION (1.78 Å)