1AXA
ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
Summary for 1AXA
| Entry DOI | 10.2210/pdb1axa/pdb |
| Descriptor | HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE (3 entities in total) |
| Functional Keywords | hiv protease, mutant, aspartic protease, hydrolase, acid proteinase, aspartyl protease |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 2 |
| Total formula weight | 22833.04 |
| Authors | Hong, L.,Hartsuck, J.A.,Foundling, S.,Ermolieff, J.,Tang, J. (deposition date: 1997-10-13, release date: 1998-04-15, Last modification date: 2024-02-07) |
| Primary citation | Hong, L.,Hartsuck, J.A.,Foundling, S.,Ermolieff, J.,Tang, J. Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant. Protein Sci., 7:300-305, 1998 Cited by PubMed: 9521105PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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