1AXA

ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT

Summary for 1AXA

DescriptorHIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE (3 entities in total)
Functional Keywordshiv protease, mutant, aspartic protease, hydrolase, acid proteinase, aspartyl protease
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P03366
Total number of polymer chains2
Total molecular weight22833.04
Authors
Hong, L.,Hartsuck, J.A.,Foundling, S.,Ermolieff, J.,Tang, J. (deposition date: 1997-10-13, release date: 1998-04-15, Last modification date: 2011-07-13)
Primary citation
Hong, L.,Hartsuck, J.A.,Foundling, S.,Ermolieff, J.,Tang, J.
Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant.
Protein Sci., 7:300-305, 1998
PubMed: 9521105 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers120.5%16.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1axa
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Molmil generated image of 1axa
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Molmil generated image of 1axa
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