1AWH

NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT

1AWH の概要

• エントリーDOI: 10.2210/pdb1awh/pdb
• 分子名称: ALPHA THROMBIN, 3-ACETOXY-17-(1-FORMYL-5-METHYL-3-OXO-HEX-4-ENYL)-16-HYDROXY-4,10,13,14-TETRAMETHYL-2,3,4,5,6,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-4-CARBOXYLIC ACID, ... (4 entities in total)
• 機能のキーワード: proteinase, blood coagulation, trypsin like proteinase, complex (protease-inhibitor), complex (protease-inhibitor) complex, complex (protease/inhibitor)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 68838.91

構造登録者

Jhoti, H.,Cleasby, A.,Wonacott, A. (登録日: 1997-10-02, 公開日: 1998-10-28, 最終更新日: 2024-04-03)

• 主引用文献: Weir, M.P.,Bethell, S.S.,Cleasby, A.,Campbell, C.J.,Dennis, R.J.,Dix, C.J.,Finch, H.,Jhoti, H.,Mooney, C.J.,Patel, S.,Tang, C.M.,Ward, M.,Wonacott, A.J.,Wharton, C.W.; Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.; Biochemistry, 37:6645-6657, 1998; PubMed: 9578548; DOI: 10.1021/bi972499o

実験手法

X-RAY DIFFRACTION (3 Å)