1AVZ
V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN
Summary for 1AVZ
Entry DOI | 10.2210/pdb1avz/pdb |
Descriptor | NEGATIVE FACTOR, FYN TYROSINE KINASE (2 entities in total) |
Functional Keywords | complex (myristylation-transferase), gtp-binding, hiv-1, phosphorylation, nef, sh3 domain, fyn, tyrosine kinase, complex (myristylation-transferase) complex, complex (myristylation/transferase) |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Host cell membrane ; Lipid-anchor ; Cytoplasmic side : P03406 Cytoplasm: P06241 |
Total number of polymer chains | 3 |
Total formula weight | 41661.51 |
Authors | Arold, S.,Franken, P.,Dumas, C. (deposition date: 1997-09-23, release date: 1998-03-25, Last modification date: 2024-05-22) |
Primary citation | Arold, S.,Franken, P.,Strub, M.P.,Hoh, F.,Benichou, S.,Benarous, R.,Dumas, C. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure, 5:1361-1372, 1997 Cited by PubMed: 9351809DOI: 10.1016/S0969-2126(97)00286-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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