1AVZ

V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN

Summary for 1AVZ

Entry DOI	10.2210/pdb1avz/pdb
Descriptor	NEGATIVE FACTOR, FYN TYROSINE KINASE (2 entities in total)
Functional Keywords	complex (myristylation-transferase), gtp-binding, hiv-1, phosphorylation, nef, sh3 domain, fyn, tyrosine kinase, complex (myristylation-transferase) complex, complex (myristylation/transferase)
Biological source	Human immunodeficiency virus 1 More
Cellular location	Host cell membrane ; Lipid-anchor ; Cytoplasmic side : P03406 Cytoplasm: P06241
Total number of polymer chains	3
Total formula weight	41661.51
Authors	Arold, S.,Franken, P.,Dumas, C. (deposition date: 1997-09-23, release date: 1998-03-25, Last modification date: 2023-08-02)
Primary citation	Arold, S.,Franken, P.,Strub, M.P.,Hoh, F.,Benichou, S.,Benarous, R.,Dumas, C. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure, 5:1361-1372, 1997 Cited by PubMed: 9351809 DOI: 10.1016/S0969-2126(97)00286-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation