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1ATK

CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH THE COVALENT INHIBITOR E-64

Summary for 1ATK
Entry DOI10.2210/pdb1atk/pdb
DescriptorCATHEPSIN K, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE (3 entities in total)
Functional Keywordshydrolase, sulfhydryl proteinase
Biological sourceHomo sapiens (human)
Cellular locationLysosome: P43235
Total number of polymer chains1
Total formula weight23883.91
Authors
Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (deposition date: 1996-12-19, release date: 1998-02-04, Last modification date: 2023-08-02)
Primary citationZhao, B.,Janson, C.A.,Amegadzie, B.Y.,D'Alessio, K.,Griffin, C.,Hanning, C.R.,Jones, C.,Kurdyla, J.,McQueney, M.,Qiu, X.,Smith, W.W.,Abdel-Meguid, S.S.
Crystal structure of human osteoclast cathepsin K complex with E-64.
Nat.Struct.Biol., 4:109-111, 1997
Cited by
PubMed: 9033588
DOI: 10.1038/nsb0297-109
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

數據於2024-03-27公開中

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