1AQZ

CRYSTAL STRUCTURE OF A HIGHLY SPECIFIC ASPERGILLUS RIBOTOXIN, RESTRICTOCIN

1AQZ の概要

• エントリーDOI: 10.2210/pdb1aqz/pdb
• 分子名称: RESTRICTOCIN, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: ribotoxin, ribosome-inactivating protein, protein-rna specific interaction, laue diffraction, cell-entry activity
• 由来する生物種: Aspergillus restrictus
• 細胞内の位置: Secreted: P67876
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34062.70

構造登録者

Yang, X.,Moffat, K. (登録日: 1997-08-04, 公開日: 1997-11-12, 最終更新日: 2024-10-30)

主引用文献

Yang, X.,Moffat, K.
Insights into specificity of cleavage and mechanism of cell entry from the crystal structure of the highly specific Aspergillus ribotoxin, restrictocin.
Structure, 4:837-852, 1996

PubMed Abstract: Restriction, a highly specific ribotoxin made by the fungus Aspergillus restrictus, cleaves a single phosphodiester bond in the 28S RNA of eukaryotic ribosomes, inhibiting protein synthesis. The sequence around this cleavage site is a binding site for elongation factors, and is conserved in all cytoplasmic ribosomes. The catalytic mechanism of restrictocin and the reasons for its high substrate specificity are unknown. No structure has been determined for any other member of the Aspergillus ribotoxin family.

PubMed: 8805570
DOI: 10.1016/S0969-2126(96)00090-1

実験手法

X-RAY DIFFRACTION (1.7 Å)