1APF

ANTHOPLEURIN-B, NMR, 20 STRUCTURES

Summary for 1APF

• Entry DOI: 10.2210/pdb1apf/pdb
• Descriptor: ANTHOPLEURIN-B (1 entity in total)
• Functional Keywords: toxin, sea anemone, cardiac stimulant
• Biological source: Anthopleura xanthogrammica (giant green sea anemone)
• Cellular location: Secreted : P01531
• Total number of polymer chains: 1
• Total formula weight: 5281.07

Authors

Monks, S.A.,Pallaghy, P.K.,Scanlon, M.J.,Norton, R.S. (deposition date: 1995-05-30, release date: 1996-07-11, Last modification date: 2024-10-23)

Primary citation

Monks, S.A.,Pallaghy, P.K.,Scanlon, M.J.,Norton, R.S.
Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A.
Structure, 3:791-803, 1995

PubMed Abstract: The polypeptide anthopleurin-B (AP-B) is one of a number of related toxins produced by sea anemones. AP-B delays inactivation of the voltage-gated sodium channel of excitable tissue. In the mammalian heart, this effect is manifest as an increase in the force of contraction. As a result, there is interest in exploiting the anthopleurins as lead compounds in the design of novel cardiac stimulants. Essential to this endeavour is a high-resolution solution structure of the molecule describing the positions of functionally important side chains.

PubMed: 7582896
DOI: 10.1016/S0969-2126(01)00214-3

Experimental method

SOLUTION NMR