1AH1

CTLA-4, NMR, 20 STRUCTURES

1AH1 の概要

• エントリーDOI: 10.2210/pdb1ah1/pdb
• 分子名称: CTLA-4, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: immunoreceptor, t cell receptor, immune response, immunoglobulin
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P16410
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15330.06

構造登録者

Metzler, W.J.,Bajorath, J.,Fenderson, W.,Shaw, S.-Y.,Peach, R.,Constantine, K.L.,Naemura, J.,Leytze, G.,Lavoie, T.B.,Mueller, L.,Linsley, P.S. (登録日: 1997-04-11, 公開日: 1998-04-15, 最終更新日: 2020-07-29)

• 主引用文献: Metzler, W.J.,Bajorath, J.,Fenderson, W.,Shaw, S.Y.,Constantine, K.L.,Naemura, J.,Leytze, G.,Peach, R.J.,Lavoie, T.B.,Mueller, L.,Linsley, P.S.; Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.; Nat.Struct.Biol., 4:527-531, 1997; PubMed: 9228944; DOI: 10.1038/nsb0797-527

実験手法

SOLUTION NMR