1AGJ

EPIDERMOLYTIC TOXIN A FROM STAPHYLOCOCCUS AUREUS

1AGJ の概要

• エントリーDOI: 10.2210/pdb1agj/pdb
• 分子名称: EPIDERMOLYTIC TOXIN A (2 entities in total)
• 機能のキーワード: hydrolase, serine protease
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53970.22

構造登録者

Cavarelli, J. (登録日: 1997-03-25, 公開日: 1997-09-26, 最終更新日: 2024-02-07)

主引用文献

Cavarelli, J.,Prevost, G.,Bourguet, W.,Moulinier, L.,Chevrier, B.,Delagoutte, B.,Bilwes, A.,Mourey, L.,Rifai, S.,Piemont, Y.,Moras, D.
The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7 A resolution.
Structure, 5:813-824, 1997

PubMed Abstract: Staphylococcal epidermolytic toxins A and B (ETA and ETB) are responsible for the staphylococcal scalded skin syndrome of newborn and young infants; this condition can appear just a few hours after birth. These toxins cause the disorganization and disruption of the region between the stratum spinosum and the stratum granulosum--two of the three cellular layers constituting the epidermis. The physiological substrate of ETA is not known and, consequently, its mode of action in vivo remains an unanswered question. Determination of the structure of ETA and its comparison with other serine proteases may reveal insights into ETA's catalytic mechanism.

PubMed: 9261066
DOI: 10.1016/S0969-2126(97)00235-9

実験手法

X-RAY DIFFRACTION (1.7 Å)