1AFS

RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE

Summary for 1AFS

• Entry DOI: 10.2210/pdb1afs/pdb
• Descriptor: 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TESTOSTERONE, ... (4 entities in total)
• Functional Keywords: oxidoreductase, nad
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Cytoplasm: P23457
• Total number of polymer chains: 2
• Total formula weight: 76448.95

Authors

Bennett, M.J.,Albert, R.H.,Jez, J.M.,Ma, H.,Penning, T.M.,Lewis, M. (deposition date: 1997-03-13, release date: 1997-10-08, Last modification date: 2023-08-02)

• Primary citation: Bennett, M.J.,Albert, R.H.,Jez, J.M.,Ma, H.,Penning, T.M.,Lewis, M.; Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.; Structure, 5:799-812, 1997; PubMed: 9261071; DOI: 10.1016/S0969-2126(97)00234-7

Experimental method

X-RAY DIFFRACTION (2.5 Å)