1AD6

DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR

1AD6 の概要

• エントリーDOI: 10.2210/pdb1ad6/pdb
• 分子名称: RETINOBLASTOMA TUMOR SUPPRESSOR (2 entities in total)
• 機能のキーワード: transcription regulation, tumor suppressor, dna-binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21335.74

構造登録者

Kim, H.Y.,Cho, Y. (登録日: 1997-02-21, 公開日: 1998-08-26, 最終更新日: 2024-02-07)

主引用文献

Kim, H.Y.,Cho, Y.
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box.
Nat.Struct.Biol., 4:390-395, 1997

PubMed Abstract: The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.

PubMed: 9145110
DOI: 10.1038/nsb0597-390

実験手法

X-RAY DIFFRACTION (2.3 Å)