1A94

STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES

1A94 の概要

関連するBIRD辞書のPRD_IDPRD_000349
分子名称PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
機能のキーワードhuman immunodeficiency virus protease, rous sarcoma virus protease, protein-mediated interaction, viral maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Human immunodeficiency virus 1
細胞内の位置Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P03367
ポリマー鎖数4
分子量合計44628.55
構造登録者
Wu, J.,Adomat, J.M.,Ridky, T.W.,Louis, J.M.,Leis, J.,Harrison, R.W.,Weber, I.T. (登録日: 1998-04-16, 公開日: 1999-01-13, 最終更新日: 2012-12-12)
主引用文献
Wu, J.,Adomat, J.M.,Ridky, T.W.,Louis, J.M.,Leis, J.,Harrison, R.W.,Weber, I.T.
Structural basis for specificity of retroviral proteases.
Biochemistry, 37:4518-4526, 1998
PubMed: 9521772 (主引用文献が同じPDBエントリー)
DOI: 10.1021/bi972183g
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers17013.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード