1A94

STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES

1A94 の概要

• エントリーDOI: 10.2210/pdb1a94/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000349
• 分子名称: PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
• 機能のキーワード: human immunodeficiency virus protease, rous sarcoma virus protease, protein-mediated interaction, viral maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 44628.55

構造登録者

Wu, J.,Adomat, J.M.,Ridky, T.W.,Louis, J.M.,Leis, J.,Harrison, R.W.,Weber, I.T. (登録日: 1998-04-16, 公開日: 1999-01-13, 最終更新日: 2024-02-07)

• 主引用文献: Wu, J.,Adomat, J.M.,Ridky, T.W.,Louis, J.M.,Leis, J.,Harrison, R.W.,Weber, I.T.; Structural basis for specificity of retroviral proteases.; Biochemistry, 37:4518-4526, 1998; PubMed: 9521772; DOI: 10.1021/bi972183g

実験手法

X-RAY DIFFRACTION (2 Å)