1A92

OLIGOMERIZATION DOMAIN OF HEPATITIS DELTA ANTIGEN

1A92 の概要

• エントリーDOI: 10.2210/pdb1a92/pdb
• 分子名称: DELTA ANTIGEN (2 entities in total)
• 機能のキーワード: leucine zipper, coiled-coil, oligomerization, hepatitis delta, hdv
• 由来する生物種: Hepatitis delta virus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 24024.20

構造登録者

Zuccola, H.J.,Hogle, J.M. (登録日: 1998-04-15, 公開日: 1999-06-08, 最終更新日: 2024-02-07)

主引用文献

Zuccola, H.J.,Rozzelle, J.E.,Lemon, S.M.,Erickson, B.W.,Hogle, J.M.
Structural basis of the oligomerization of hepatitis delta antigen.
Structure, 6:821-830, 1998

PubMed Abstract: The hepatitis D virus (HDV) is a small satellite virus of hepatitis B virus (HBV). Coinfection with HBV and HDV causes severe liver disease in humans. The small 195 amino-acid form of the hepatitis delta antigen (HDAg) functions as a trans activator of HDV replication. A larger form of the protein containing a 19 amino acid C-terminal extension inhibits viral replication. Both of these functions are mediated in part by a stretch of amino acids predicted to form a coiled coil (residues 13-48) that is common to both forms. It is believed that HDAg forms dimers and higher ordered structures through this coiled-coil region.

PubMed: 9687364
DOI: 10.1016/S0969-2126(98)00084-7

実験手法

X-RAY DIFFRACTION (1.8 Å)