1A8M
TUMOR NECROSIS FACTOR ALPHA, R31D MUTANT
Summary for 1A8M
Entry DOI | 10.2210/pdb1a8m/pdb |
Descriptor | TUMOR NECROSIS FACTOR ALPHA (2 entities in total) |
Functional Keywords | lymphokine, cytokine, cytotoxin |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375 |
Total number of polymer chains | 3 |
Total formula weight | 51985.65 |
Authors | Reed, C.,Fu, Z.-Q.,Wu, J.,Xue, Y.-N.,Harrison, R.W.,Chen, M.-J.,Weber, I.T. (deposition date: 1998-03-27, release date: 1998-06-17, Last modification date: 2023-08-02) |
Primary citation | Reed, C.,Fu, Z.Q.,Wu, J.,Xue, Y.N.,Harrison, R.W.,Chen, M.J.,Weber, I.T. Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2. Protein Eng., 10:1101-1107, 1997 Cited by PubMed: 9488135DOI: 10.1093/protein/10.10.1101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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