1A8K
CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
1A8K の概要
エントリーDOI | 10.2210/pdb1a8k/pdb |
関連するBIRD辞書のPRD_ID | PRD_000349 |
分子名称 | HIV PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total) |
機能のキーワード | human immunodeficiency virus protease, proton-mediated interaction, viral maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Human immunodeficiency virus 1 |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 44885.34 |
構造登録者 | Weber, I.T.,Wu, J.,Adomat, J.,Harrison, R.W.,Kimmel, A.R.,Wondrak, E.M.,Louis, J.M. (登録日: 1998-03-27, 公開日: 1999-01-13, 最終更新日: 2024-05-22) |
主引用文献 | Weber, I.T.,Wu, J.,Adomat, J.,Harrison, R.W.,Kimmel, A.R.,Wondrak, E.M.,Louis, J.M. Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates. Eur.J.Biochem., 249:523-530, 1997 Cited by PubMed: 9370363DOI: 10.1111/j.1432-1033.1997.00523.x 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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