1A8K

CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES

1A8K の概要

• エントリーDOI: 10.2210/pdb1a8k/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000349
• 分子名称: HIV PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
• 機能のキーワード: human immunodeficiency virus protease, proton-mediated interaction, viral maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 44885.34

構造登録者

Weber, I.T.,Wu, J.,Adomat, J.,Harrison, R.W.,Kimmel, A.R.,Wondrak, E.M.,Louis, J.M. (登録日: 1998-03-27, 公開日: 1999-01-13, 最終更新日: 2024-05-22)

• 主引用文献: Weber, I.T.,Wu, J.,Adomat, J.,Harrison, R.W.,Kimmel, A.R.,Wondrak, E.M.,Louis, J.M.; Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates.; Eur.J.Biochem., 249:523-530, 1997; PubMed: 9370363; DOI: 10.1111/j.1432-1033.1997.00523.x

実験手法

X-RAY DIFFRACTION (2 Å)