1A8J

IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME

1A8J の概要

• エントリーDOI: 10.2210/pdb1a8j/pdb
• 分子名称: IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG), N-L-ALPHA-ASPARTYL L-PHENYLALANINE 1-METHYL ESTER (2 entities in total)
• 機能のキーワード: aspartame, ligand binding, immunotherapeutic agent, surrogate receptor, mcg(human) bence-jones dimer, immunoglobulin
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46254.73

構造登録者

Edmundson, A.B.,Manion, C.V. (登録日: 1998-03-26, 公開日: 1998-06-17, 最終更新日: 2024-10-09)

主引用文献

Edmundson, A.B.,Manion, C.V.
Treatment of osteoarthritis with aspartame.
Clin.Pharmacol.Ther., 63:580-593, 1998

PubMed Abstract: The binding of sweet-tasting compounds in a human (Mcg) Bence-Jones dimer has been characterized by x-ray crystallography. Aspartame binding in this immunoglobulin fragment is remarkable. Unexpected pain relief noted by A.B.E., a crystallographer with diagnosed osteoarthritis, suggested that the accommodation of aspartame in the active site of the dimer may represent surrogate binding by other proteins, with analgesia as the outcome.

PubMed: 9630831

実験手法

X-RAY DIFFRACTION (2.7 Å)