1A7X

FKBP12-FK1012 COMPLEX

Summary for 1A7X

Entry DOI	10.2210/pdb1a7x/pdb
Descriptor	FKBP12, BENZYL-CARBAMIC ACID [8-DEETHYL-ASCOMYCIN-8-YL]ETHYL ESTER (3 entities in total)
Functional Keywords	isomerase, immunophilin
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol : P62942
Total number of polymer chains	2
Total formula weight	24614.17
Authors	Schultz, L.W.,Clardy, J. (deposition date: 1998-03-18, release date: 1998-06-17, Last modification date: 2024-05-22)
Primary citation	Schultz, L.W.,Clardy, J. Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12. Bioorg.Med.Chem.Lett., 8:1-6, 1998 Cited by PubMed Abstract: A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design. PubMed: 9871618 DOI: 10.1016/S0960-894X(97)10195-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation