1A59

COLD-ACTIVE CITRATE SYNTHASE

1A59 の概要

• エントリーDOI: 10.2210/pdb1a59/pdb
• 分子名称: CITRATE SYNTHASE, COENZYME A, CITRIC ACID (3 entities in total)
• 機能のキーワード: cold-activity
• 由来する生物種: Antarctic bacterium DS2-3R
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42708.75

構造登録者

Russell, R.J.M.,Gerike, U.,Danson, M.J.,Hough, D.W.,Taylor, G.L. (登録日: 1998-02-20, 公開日: 1999-03-30, 最終更新日: 2024-02-07)

主引用文献

Russell, R.J.,Gerike, U.,Danson, M.J.,Hough, D.W.,Taylor, G.L.
Structural adaptations of the cold-active citrate synthase from an Antarctic bacterium.
Structure, 6:351-361, 1998

PubMed Abstract: The structural basis of adaptation of enzymes to low temperature is poorly understood. Dimeric citrate synthase has been used as a model enzyme to study the structural basis of thermostability, the structure of the enzyme from organisms living in habitats at 55 degrees C and 100 degrees C having previously been determined. Here the study is extended to include a citrate synthase from an Antarctic bacterium, allowing us to explore the structural basis of cold activity and thermostability across the whole temperature range over which life is known to exit.

PubMed: 9551556
DOI: 10.1016/S0969-2126(98)00037-9

実験手法

X-RAY DIFFRACTION (2.09 Å)