1A4G

INFLUENZA VIRUS B/BEIJING/1/87 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR

Summary for 1A4G

• Entry DOI: 10.2210/pdb1a4g/pdb
• Descriptor: NEURAMINIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase, glycosidase, glycosylated protein
• Biological source: Influenza B virus (STRAIN B/BEIJING/1/87)
• Cellular location: Virion membrane : P27907
• Total number of polymer chains: 2
• Total formula weight: 88085.78

Authors

Cleasby, A.,Singh, O.,Skarzynski, T.,Wonacott, A.J. (deposition date: 1998-01-29, release date: 1999-03-02, Last modification date: 2023-08-02)

• Primary citation: Taylor, N.R.,Cleasby, A.,Singh, O.,Skarzynski, T.,Wonacott, A.J.,Smith, P.W.,Sollis, S.L.,Howes, P.D.,Cherry, P.C.,Bethell, R.,Colman, P.,Varghese, J.; Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.; J.Med.Chem., 41:798-807, 1998; PubMed: 9526556; DOI: 10.1021/jm9703754

Experimental method

X-RAY DIFFRACTION (2.2 Å)