1A2N

STRUCTURE OF THE C115A MUTANT OF MURA COMPLEXED WITH THE FLUORINATED ANALOG OF THE REACTION TETRAHEDRAL INTERMEDIATE

1A2N の概要

• エントリーDOI: 10.2210/pdb1a2n/pdb
• 分子名称: UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL-3-FLUORO-2-PHOSPHONOOXY)PROPIONIC ACID (3 entities in total)
• 機能のキーワード: transferase, peptidoglycan synthesis, enolpyruvyl transferase, udp-n-acetylglucosamine
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45632.86

構造登録者

Skarzynski, T. (登録日: 1998-01-06, 公開日: 1998-04-29, 最終更新日: 2023-08-02)

• 主引用文献: Skarzynski, T.,Kim, D.H.,Lees, W.J.,Walsh, C.T.,Duncan, K.; Stereochemical course of enzymatic enolpyruvyl transfer and catalytic conformation of the active site revealed by the crystal structure of the fluorinated analogue of the reaction tetrahedral intermediate bound to the active site of the C115A mutant of MurA; Biochemistry, 37:2572-2577, 1998; PubMed: 9485407; DOI: 10.1021/bi9722608

実験手法

X-RAY DIFFRACTION (2.8 Å)