1A0R

HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA

Summary for 1A0R

• Entry DOI: 10.2210/pdb1a0r/pdb
• Descriptor: TRANSDUCIN (BETA SUBUNIT), TRANSDUCIN (GAMMA SUBUNIT), PHOSDUCIN, ... (5 entities in total)
• Functional Keywords: phosducin, transducin, beta-gamma, signal transduction, regulation, phosphorylation, g proteins, thioredoxin, vision, meka, complex (transducer-transduction), post-translational modification, farnesyl, farnesylation, complex (transducer-transduction) complex, complex (transducer/transduction)
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 3
• Total formula weight: 73467.69

Authors

Loew, A.,Ho, Y.-K.,Blundell, T.L.,Bax, B. (deposition date: 1997-12-05, release date: 1998-12-30, Last modification date: 2024-10-16)

Primary citation

Loew, A.,Ho, Y.K.,Blundell, T.,Bax, B.
Phosducin induces a structural change in transducin beta gamma.
Structure, 6:1007-1019, 1998

PubMed Abstract: Phosducin binds tightly to the beta gamma subunits (Gt beta gamma) of the heterotrimeric G protein transducin, preventing Gt beta gamma reassociation with Gt alpha-GDP and thereby inhibiting the G-protein cycle. Phosducin-like proteins appear to be widely distributed and may play important roles in regulating many heterotrimeric G-protein signaling pathways.

PubMed: 9739091
DOI: 10.1016/S0969-2126(98)00102-6

Experimental method

X-RAY DIFFRACTION (2.8 Å)