1A0L

HUMAN BETA-TRYPTASE: A RING-LIKE TETRAMER WITH ACTIVE SITES FACING A CENTRAL PORE

1A0L の概要

• エントリーDOI: 10.2210/pdb1a0l/pdb
• 分子名称: BETA-TRYPTASE, (2S)-3-(4-carbamimidoylphenyl)-2-hydroxypropanoic acid (3 entities in total)
• 機能のキーワード: trypsin-like serine proteinase, tetramer, heparin, allergy, asthma, serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P20231
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 110410.10

構造登録者

Pereira, P.J.B.,Bergner, A.,Macedo-Ribeiro, S.,Huber, R.,Matschiner, G.,Fritz, H.,Sommerhoff, C.P.,Bode, W. (登録日: 1997-12-03, 公開日: 1999-03-23, 最終更新日: 2011-07-13)

• 主引用文献: Pereira, P.J.,Bergner, A.,Macedo-Ribeiro, S.,Huber, R.,Matschiner, G.,Fritz, H.,Sommerhoff, C.P.,Bode, W.; Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.; Nature, 392:306-311, 1998; PubMed: 9521329; DOI: 10.1038/32703

実験手法

X-RAY DIFFRACTION (3 Å)