1ZXB
Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives
Summary for 1ZXB
Entry DOI | 10.2210/pdb1zxb/pdb |
Related | 1NHD 1NHG 1NHW 1NNU 1ZSN 1ZW1 |
Descriptor | enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)-N-METHYLBENZAMIDE (3 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
Total number of polymer chains | 2 |
Total formula weight | 78143.06 |
Authors | Freundlich, J.S.,Anderson, J.W.,Sarantakis, D.,Shieh, H.M.,Yu, M.,Lucumi, E.,Kuo, M.,Schiehser, G.A.,Jacobus, D.P.,Jacobs Jr., W.R.,Fidock, D.A.,Sacchettini, J.C. (deposition date: 2005-06-07, release date: 2006-06-13, Last modification date: 2023-08-23) |
Primary citation | Freundlich, J.S.,Anderson, J.W.,Sarantakis, D.,Shieh, H.M.,Yu, M.,Valderramos, J.C.,Lucumi, E.,Kuo, M.,Jacobs, W.R.,Fidock, D.A.,Schiehser, G.A.,Jacobus, D.P.,Sacchettini, J.C. Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives. Bioorg.Med.Chem.Lett., 15:5247-5252, 2005 Cited by PubMed: 16198563DOI: 10.1016/j.bmcl.2005.08.044 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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