1ZSK

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 6-Carbamimidoyl-4-(3-hydroxy-2-methyl-benzoylamino)-naphthalene-2-carboxylic acid methyl ester

Summary for 1ZSK

• Entry DOI: 10.2210/pdb1zsk/pdb
• Related: 1ZSJ
• Descriptor: Coagulation factor XI, SULFATE ION, BICARBONATE ION, ... (5 entities in total)
• Functional Keywords: fxia, inhibitors, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P03951
• Total number of polymer chains: 1
• Total formula weight: 27382.90

Authors

Guo, Z.,Bannister, T.,Noll, R.,Jin, L.,Rynkiewicz, M.,Bibbins, F.,Magee, S.,Gorga, J.,Babine, R.E.,Strickler, J.E.,Meyers, H.V.,Abdel-Meguid, S.S. (deposition date: 2005-05-24, release date: 2006-05-23, Last modification date: 2024-10-30)

• Primary citation: Guo, Z.,Bannister, T.,Noll, R.,Jin, L.,Rynkiewicz, M.,Bibbins, F.,Magee, S.,Gorga, J.,Babine, R.E.,Strickler, J.E.,Meyers, H.V.,Abdel-Meguid, S.S.; Synthesis and Optimization of Potent and Selective Inhibitors for Human Factor XIa: Substituted Naphthamidine Series; To be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)