1ZS0
Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer)
Summary for 1ZS0
Entry DOI | 10.2210/pdb1zs0/pdb |
Descriptor | Neutrophil collagenase, CALCIUM ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | phosphonic inhibitor, sulphonamide junction, stereoselective inhibition, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasmic granule: P22894 |
Total number of polymer chains | 1 |
Total formula weight | 18917.35 |
Authors | Pochetti, G.,Gavuzzo, E.,Campestre, C.,Agamennone, M.,Tortorella, P.,Consalvi, V.,Gallina, C.,Hiller, O.,Tschesche, H.,Tucker, P.A.,Mazza, F. (deposition date: 2005-05-23, release date: 2006-05-02, Last modification date: 2023-08-23) |
Primary citation | Pochetti, G.,Gavuzzo, E.,Campestre, C.,Agamennone, M.,Tortorella, P.,Consalvi, V.,Gallina, C.,Hiller, O.,Tschesche, H.,Tucker, P.A.,Mazza, F. Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J.Med.Chem., 49:923-931, 2006 Cited by PubMed: 16451058DOI: 10.1021/jm050787+ PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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