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1ZBG

Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2

Summary for 1ZBG
Entry DOI10.2210/pdb1zbg/pdb
Related1FQX 1IIQ 1LZQ 1M0B 1Z8C 1ZJ7 1ZLF
Related PRD IDPRD_000385
DescriptorPROTEASE RETROPEPSIN, CHLORIDE ION, N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, ... (5 entities in total)
Functional Keywordshiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains2
Total formula weight22624.92
Authors
Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J. (deposition date: 2005-04-08, release date: 2006-04-18, Last modification date: 2023-08-23)
Primary citationDuskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J.
Mutational Study of Pseudopeptide Inhibitor Binding to HIV-1 Protease; Analysis of Four X-ray Structures
To be Published,
Experimental method
X-RAY DIFFRACTION (1.995 Å)
Structure validation

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PDB entries from 2024-03-27

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