1Z8J

Crystal structure of the thrombin mutant G193P bound to PPACK

Summary for 1Z8J

• Entry DOI: 10.2210/pdb1z8j/pdb
• Related: 1Z8I
• Related PRD ID: PRD_000020
• Descriptor: Thrombin light chain, Thrombin heavy chain, ZINC ION, ... (7 entities in total)
• Functional Keywords: serine protease, oxyanion hole, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 2
• Total formula weight: 35360.85

Authors

Bobofchak, K.M.,Pineda, A.O.,Mathews, F.S.,Di Cera, E. (deposition date: 2005-03-30, release date: 2005-05-17, Last modification date: 2024-03-13)

• Primary citation: Bobofchak, K.M.,Pineda, A.O.,Mathews, F.S.,Di Cera, E.; Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases; J.Biol.Chem., 280:25644-25650, 2005; PubMed: 15890651; DOI: 10.1074/jbc.M503499200

Experimental method

X-RAY DIFFRACTION (2 Å)