1U9Q
Crystal structure of cruzain bound to an alpha-ketoester
Summary for 1U9Q
Entry DOI | 10.2210/pdb1u9q/pdb |
Related | 1F29 1F2A 1F2B 1F2C 1ME3 1ME4 |
Descriptor | cruzipain, [1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER (3 entities in total) |
Functional Keywords | clan-ca cysteine protease; covalent inhibitor, hydrolase |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 1 |
Total formula weight | 23123.58 |
Authors | Lange, M.,Weston, S.G.,Cheng, H.,Culliane, M.,Fiorey, M.M.,Grisostomi, C.,Hardy, L.W.,Hartstough, D.S.,Pallai, P.V.,Tilton, R.F.,Baldino, C.M.,Brinen, L.S.,Engel, J.C.,Choe, Y.,Price, M.S.,Craik, C.S. (deposition date: 2004-08-10, release date: 2005-03-29, Last modification date: 2023-08-23) |
Primary citation | Choe, Y.,Brinen, L.S.,Price, M.S.,Engel, J.C.,Lange, M.,Grisostomi, C.,Weston, S.G.,Pallai, P.V.,Cheng, H.,Hardy, L.W.,Hartsough, D.S.,McMakin, M.,Tilton, R.F.,Baldino, C.M.,Craik, C.S. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease Bioorg.Med.Chem., 13:2141-2156, 2005 Cited by PubMed: 15727867DOI: 10.1016/j.bmc.2004.12.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report