1TVA

HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE

Summary for 1TVA

• Entry DOI: 10.2210/pdb1tva/pdb
• Related: 1BPZ 1TV9
• Descriptor: 5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... (8 entities in total)
• Functional Keywords: nucleotidyltransferase, dna repair, dna mismatch, base excision repair, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48161.60

Authors

Krahn, J.M.,Beard, W.A.,Wilson, S.H. (deposition date: 2004-06-29, release date: 2004-11-23, Last modification date: 2024-02-14)

• Primary citation: Krahn, J.M.,Beard, W.A.,Wilson, S.H.; Structural insights into DNA polymerase Beta deterrents for misincorporation support an induced-fit mechanism for fidelity; Structure, 12:1823-1832, 2004; PubMed: 15458631; DOI: 10.1016/j.str.2004.08.001

Experimental method

X-RAY DIFFRACTION (2.6 Å)