1TPU

S96P CHANGE IS A SECOND-SITE SUPPRESSOR FOR H95N SLUGGISH MUTANT TRIOSEPHOSPHATE ISOMERASE

Summary for 1TPU

• Entry DOI: 10.2210/pdb1tpu/pdb
• Descriptor: TRIOSEPHOSPHATE ISOMERASE, PHOSPHOGLYCOLOHYDROXAMIC ACID (3 entities in total)
• Functional Keywords: isomerase(intramolecular oxidoreductase)
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 2
• Total formula weight: 53374.58

Authors

Zhang, Z.,Sugio, S.,Komives, E.A.,Liu, K.D.,Stock, A.M.,Narayana, N.,Xuong, Ng.H.,Knowles, J.R.,Petsko, G.A.,Ringe, D. (deposition date: 1994-11-07, release date: 1995-04-20, Last modification date: 2024-02-14)

• Primary citation: Komives, E.A.,Lougheed, J.C.,Zhang, Z.,Sugio, S.,Narayana, N.,Xuong, N.H.,Petsko, G.A.,Ringe, D.; The structural basis for pseudoreversion of the H95N lesion by the secondary S96P mutation in triosephosphate isomerase.; Biochemistry, 35:15474-15484, 1996; PubMed: 8952501; DOI: 10.1021/bi961556v

Experimental method

X-RAY DIFFRACTION (1.9 Å)