1TII

ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB

Summary for 1TII

• Entry DOI: 10.2210/pdb1tii/pdb
• Descriptor: HEAT LABILE ENTEROTOXIN TYPE IIB, ... (4 entities in total)
• Functional Keywords: adp-ribosyl transferase, adp-ribosylation, enterotoxin, ganglioside receptor
• Biological source: Escherichia coli; More
• Total number of polymer chains: 7
• Total formula weight: 81134.01

Authors

Van Den Akker, F.,Hol, W.G.J. (deposition date: 1996-03-20, release date: 1996-08-17, Last modification date: 2024-10-23)

Primary citation

van den Akker, F.,Sarfaty, S.,Twiddy, E.M.,Connell, T.D.,Holmes, R.K.,Hol, W.G.
Crystal structure of a new heat-labile enterotoxin, LT-IIb.
Structure, 4:665-678, 1996

PubMed Abstract: Cholera toxin from Vibrio cholerae and the type I heat-labile enterotoxins (LT-Is) from Escherichia coli are oligomeric proteins with AB5 structures. The type II heat-labile enterotoxins (LT-IIs) from E. coli are structurally similar to, but antigenically distinct from, the type I enterotoxins. The A subunits of type I and type II enterotoxins are homologous and activate adenylate cyclase by ADP-ribosylation of a G protein subunit, G8 alpha. However, the B subunits of type I and type II enterotoxins differ dramatically in amino acid sequence and ganglioside-binding specificity. The structure of LT-IIb was determined both as a prototype for other LT-IIs and to provide additional insights into structure/function relationships among members of the heat-labile enterotoxin family and the superfamily of ADP-ribosylating protein toxins.

PubMed: 8805549
DOI: 10.1016/S0969-2126(96)00073-1

Experimental method

X-RAY DIFFRACTION (2.25 Å)