1SWM

X-RAY CRYSTAL STRUCTURE OF THE FERRIC SPERM WHALE MYOGLOBIN: IMIDAZOLE COMPLEX AT 2.0 ANGSTROMS RESOLUTION

Summary for 1SWM

• Entry DOI: 10.2210/pdb1swm/pdb
• Descriptor: MYOGLOBIN, AZIDE ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: oxygen transport
• Biological source: Physeter catodon (sperm whale)
• Total number of polymer chains: 1
• Total formula weight: 17989.52

Authors

Rizzi, M.,Ascenzi, P.,Coda, A.,Brunori, M.,Bolognesi, M. (deposition date: 1992-03-03, release date: 1994-01-31, Last modification date: 2024-02-14)

Primary citation

Lionetti, C.,Guanziroli, M.G.,Frigerio, F.,Ascenzi, P.,Bolognesi, M.
X-ray crystal structure of the ferric sperm whale myoglobin: imidazole complex at 2.0 A resolution.
J.Mol.Biol., 217:409-412, 1991

PubMed Abstract: The X-ray crystal structure of the ferric sperm whale (Physeter catodon) myoglobin:imidazole complex has been refined at 2.0 A resolution, to a final R-factor of 14.8%. The overall conformation of the protein is little affected by binding of the ligand. Imidazole is co-ordinated to the heme iron at the distal site, and forces distinguishable local changes in the surrounding protein residues. His64(E7) swings out of the distal pocket and becomes substantially exposed to the solvent: nevertheless, it stabilizes the exogenous ligand by hydrogen bonding. The side-chains of residues Arg45(CD3) and Asp60(E3) are also affected by imidazole association.

PubMed: 1994031
DOI: 10.1016/0022-2836(91)90744-Q

Experimental method

X-RAY DIFFRACTION (1.8 Å)