1SI4

Crystal structure of Human hemoglobin A2 (in R2 state) at 2.2 A resolution

Summary for 1SI4

• Entry DOI: 10.2210/pdb1si4/pdb
• Related: 1SHR
• Descriptor: Hemoglobin alpha chain, Hemoglobin delta chain, CYANIDE ION, ... (5 entities in total)
• Functional Keywords: hemoglobin a2, beta thalassemia, oxygen transport, antisickling effect, oxygen storage-transport complex, oxygen storage/transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 64763.26

Authors

Sen, U.,Dasgupta, J.,Choudhury, D.,Datta, P.,Chakrabarti, A.,Chakrabarty, S.B.,Chakrabarty, A.,Dattagupta, J.K. (deposition date: 2004-02-27, release date: 2004-10-26, Last modification date: 2023-10-25)

• Primary citation: Sen, U.,Dasgupta, J.,Choudhury, D.,Datta, P.,Chakrabarti, A.,Chakrabarty, S.B.,Chakrabarty, A.,Dattagupta, J.K.; Crystal structures of HbA2 and HbE and modeling of hemoglobin delta4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb.; Biochemistry, 43:12477-12488, 2004; PubMed: 15449937; DOI: 10.1021/bi048903i

Experimental method

X-RAY DIFFRACTION (2.2 Å)