1SAC

THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT

Summary for 1SAC

Entry DOI	10.2210/pdb1sac/pdb
Descriptor	SERUM AMYLOID P COMPONENT, CALCIUM ION, ACETIC ACID (3 entities in total)
Functional Keywords	amyloid protein
Biological source	Homo sapiens (human)
Total number of polymer chains	5
Total formula weight	117053.26
Authors	White, H.E.,Emsley, J.,O'Hara, B.P.,Oliva, G.,Srinivasan, N.,Tickle, I.J.,Blundell, T.L.,Pepys, M.B.,Wood, S.P. (deposition date: 1994-01-27, release date: 1994-05-31, Last modification date: 2024-11-20)
Primary citation	Emsley, J.,White, H.E.,O'Hara, B.P.,Oliva, G.,Srinivasan, N.,Tickle, I.J.,Blundell, T.L.,Pepys, M.B.,Wood, S.P. Structure of pentameric human serum amyloid P component. Nature, 367:338-345, 1994 Cited by PubMed Abstract: The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils. PubMed: 8114934 DOI: 10.1038/367338a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation