1RS2
DHNA complex with 8-Amino-1,3-dimethyl-3,7-dihydropurine-2,6-dione
Summary for 1RS2
Entry DOI | 10.2210/pdb1rs2/pdb |
Related | 1RR5 1RRI 1RRW 1RRY 1RS4 1RSD 1RSI |
Descriptor | Dihydroneopterin aldolase, 8-AMINO-1,3-DIMETHYL-3,7-DIHYDROPURINE-2,6-DIONE (3 entities in total) |
Functional Keywords | dhna, 7, 8-dihydroneop8-amino-1, 3-dimethyl-3, 7-dihydropurine-2, 6-dioneterin aldolase, lyase |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 13964.81 |
Authors | Sanders, W.J.,Nienaber, V.L.,Lerner, C.G.,McCall, J.O.,Merrick, S.M.,Swanson, S.J.,Harlan, J.E.,Stoll, V.S.,Stamper, G.F.,Betz, S.F.,Condroski, K.R.,Meadows, R.P.,Severin, J.M.,Walter, K.A.,Magdalinos, P.,Jakob, C.G.,Wagner, R.,Beutel, B.A. (deposition date: 2003-12-09, release date: 2004-03-30, Last modification date: 2024-02-14) |
Primary citation | Sanders, W.J.,Nienaber, V.L.,Lerner, C.G.,McCall, J.O.,Merrick, S.M.,Swanson, S.J.,Harlan, J.E.,Stoll, V.S.,Stamper, G.F.,Betz, S.F.,Condroski, K.R.,Meadows, R.P.,Severin, J.M.,Walter, K.A.,Magdalinos, P.,Jakob, C.G.,Wagner, R.,Beutel, B.A. Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization. J.Med.Chem., 47:1709-1718, 2004 Cited by PubMed: 15027862DOI: 10.1021/jm030497y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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