1REJ

Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1

Summary for 1REJ

Entry DOI	10.2210/pdb1rej/pdb
Related	1ATP 1BX6 1RE8
Descriptor	cAMP-dependent protein kinase, alpha-catalytic subunit, 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-HYDROXYBENZOATE (3 entities in total)
Functional Keywords	protein kinase, natural product inhibitor, ligand binding, specificity determinants, conformational malleability, transferase
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm . Isoform 2: Cell projection, cilium, flagellum : P05132
Total number of polymer chains	1
Total formula weight	41027.71
Authors	Akamine, P.,Madhusudan,Brunton, L.L.,Ou, H.D.,Canaves, J.M.,Xuong, N.H.,Taylor, S.S. (deposition date: 2003-11-06, release date: 2004-02-24, Last modification date: 2023-08-23)
Primary citation	Akamine, P.,Madhusudan,Brunton, L.L.,Ou, H.D.,Canaves, J.M.,Xuong, N.H.,Taylor, S.S. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit Biochemistry, 43:85-96, 2004 Cited by PubMed: 14705934 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation