1RA3

DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)

Summary for 1RA3

Entry DOI	10.2210/pdb1ra3/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, METHOTREXATE, BETA-MERCAPTOETHANOL, ... (5 entities in total)
Functional Keywords	oxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	19296.30
Authors	Sawaya, M.R.,Kraut, J. (deposition date: 1996-10-28, release date: 1996-12-23, Last modification date: 2023-08-09)
Primary citation	Sawaya, M.R.,Kraut, J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36:586-603, 1997 Cited by PubMed: 9012674 DOI: 10.1021/bi962337c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation