1R78
CDK2 complex with a 4-alkynyl oxindole inhibitor
Summary for 1R78
Entry DOI | 10.2210/pdb1r78/pdb |
Related | 1fvt 1p2a |
Descriptor | Cell division protein kinase 2, 4-((3R,4S,5R)-4-AMINO-3,5-DIHYDROXY-HEX-1-YNYL)-5-FLUORO-3-[1-(3-METHOXY-1H-PYRROL-2-YL)-METH-(Z)-YLIDENE]-1,3-DIHYDRO-INDOL-2-ONE (3 entities in total) |
Functional Keywords | cyclin dependent kinase, serine/threonine protein kinase, oxindole, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34361.88 |
Authors | Luk, K.-C.,Simcox, M.E.,Schutt, A.,Rowan, K.,Thompson, T.,Chen, Y.,Kammlott, U.,DePinto, W.,Dunten, P.,Dermatakis, A. (deposition date: 2003-10-20, release date: 2004-01-20, Last modification date: 2024-02-14) |
Primary citation | Luk, K.-C.,Simcox, M.E.,Schutt, A.,Rowan, K.,Thompson, T.,Chen, Y.,Kammlott, U.,DePinto, W.,Dunten, P.,Dermatakis, A. A new series of potent oxindole inhibitors of CDK2 Bioorg.Med.Chem.Lett., 14:913-917, 2004 Cited by PubMed: 15012993DOI: 10.1016/j.bmcl.2003.12.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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