1QHA

HUMAN HEXOKINASE TYPE I COMPLEXED WITH ATP ANALOGUE AMP-PNP

Summary for 1QHA

• Entry DOI: 10.2210/pdb1qha/pdb
• Descriptor: PROTEIN (HEXOKINASE), alpha-D-glucopyranose, 6-O-phosphono-alpha-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: kinase, glycolysis, phosphotransferase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 208167.50

Authors

Rosano, C.,Sabini, E.,Deriu, D.,Magnani, M.,Bolognesi, M. (deposition date: 1999-05-11, release date: 1999-11-10, Last modification date: 2023-08-16)

Primary citation

Rosano, C.,Sabini, E.,Rizzi, M.,Deriu, D.,Murshudov, G.,Bianchi, M.,Serafini, G.,Magnani, M.,Bolognesi, M.
Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control.
Structure Fold.Des., 7:1427-1437, 1999

PubMed Abstract: Hexokinase I sets the pace of glycolysis in the brain, catalyzing the ATP-dependent phosphorylation of glucose. The catalytic properties of hexokinase I are dependent on product inhibition as well as on the action of phosphate. In vivo, a large fraction of hexokinase I is bound to the mitochondrial outer membrane, where the enzyme adopts a tetrameric assembly. The mitochondrion-bound hexokinase I is believed to optimize the ATP/ADP exchange between glucose phosphorylation and the mitochondrial oxidative phosphorylation reactions.

PubMed: 10574795
DOI: 10.1016/S0969-2126(00)80032-5

Experimental method

X-RAY DIFFRACTION (2.25 Å)