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1PWD

Covalent acyl enzyme complex of the Streptomyces R61 DD-peptidase with cephalosporin C

Summary for 1PWD
Entry DOI10.2210/pdb1pwd/pdb
Related1IKG 1IKI 1MPL
DescriptorD-alanyl-D-alanine carboxypeptidase precursor, (2R)-5-(acetyloxymethyl)-2-[(1R)-1-[[(5R)-5-azanyl-6-oxidanyl-6-oxidanylidene-hexanoyl]amino]-2-oxidanylidene-ethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid (3 entities in total)
Functional Keywordsbeta-lactam, antibiotics, penicillin binding protein, enzyme, peptidoglycan, hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceStreptomyces sp.
Total number of polymer chains1
Total formula weight37840.01
Authors
Silvaggi, N.R.,Josephine, H.R.,Pratt, R.F.,Kelly, J.A. (deposition date: 2003-07-01, release date: 2004-07-13, Last modification date: 2023-08-16)
Primary citationSilvaggi, N.R.,Josephine, H.R.,Kuzin, A.P.,Nagarajan, R.,Pratt, R.F.,Kelly, J.A.
Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin"
J.Mol.Biol., 345:521-533, 2005
Cited by
PubMed: 15581896
DOI: 10.1016/j.jmb.2004.10.076
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.2 Å)
Structure validation

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