1PTZ

Crystal structure of the human CU, Zn Superoxide Dismutase, Familial Amyotrophic Lateral Sclerosis (FALS) Mutant H43R

Summary for 1PTZ

• Entry DOI: 10.2210/pdb1ptz/pdb
• Related: 1PU0
• Descriptor: Superoxide dismutase [Cu-Zn], COPPER (I) ION, ZINC ION, ... (5 entities in total)
• Functional Keywords: sod, fals mutant, amyotrophic lateral sclerosis, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00441
• Total number of polymer chains: 2
• Total formula weight: 31950.93

Authors

DiDonato, M.,Craig, L.,Huff, M.E.,Thayer, M.M.,Cardoso, R.M.F.,Kassmann, C.J.,Lo, T.P.,Bruns, C.K.,Powers, E.T.,Kelly, J.W.,Getzoff, E.D.,Tainer, J.A. (deposition date: 2003-06-23, release date: 2003-09-09, Last modification date: 2021-10-27)

• Primary citation: DiDonato, M.,Craig, L.,Huff, M.E.,Thayer, M.M.,Cardoso, R.M.F.,Kassmann, C.J.,Lo, T.P.,Bruns, C.K.,Powers, E.T.,Kelly, J.W.,Getzoff, E.D.,Tainer, J.A.; ALS Mutants of Human Superoxide Dismutase Form Fibrous Aggregates Via Framework Destabilization; J.Mol.Biol., 332:601-615, 2003; PubMed: 12963370; DOI: 10.1016/S0022-2836(03)00889-1

Experimental method

X-RAY DIFFRACTION (1.8 Å)