1P9L

Structure of M. tuberculosis dihydrodipicolinate reductase in complex with NADH and 2,6 PDC

Summary for 1P9L

• Entry DOI: 10.2210/pdb1p9l/pdb
• Related: 1ARZ 1C3V 1DIH
• Descriptor: dihydrodipicolinate reductase, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, PYRIDINE-2,6-DICARBOXYLIC ACID, ... (5 entities in total)
• Functional Keywords: oxidoreductase, reductase, lysine biosynthesis, nadh binding specificity, tb structural genomics consortium, tbsgc, structural genomics, psi, protein structure initiative
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cytoplasm (By similarity): P72024
• Total number of polymer chains: 2
• Total formula weight: 53446.11

Authors

Cirilli, M.,Zheng, R.,Scapin, G.,Blanchard, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2003-05-12, release date: 2003-08-26, Last modification date: 2023-08-16)

• Primary citation: Cirilli, M.,Zheng, R.,Scapin, G.,Blanchard, J.S.; The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity.; Biochemistry, 42:10644-10650, 2003; PubMed: 12962488; DOI: 10.1021/bi030044v

Experimental method

X-RAY DIFFRACTION (2.3 Å)