1P7B

Crystal structure of an inward rectifier potassium channel

Summary for 1P7B

• Entry DOI: 10.2210/pdb1p7b/pdb
• Descriptor: integral membrane channel and cytosolic domains, POTASSIUM ION (3 entities in total)
• Functional Keywords: transmembrane helices, ion conduction, immunoglobulin fold, cytosolic assembly, metal transport
• Biological source: Burkholderia pseudomallei
• Total number of polymer chains: 2
• Total formula weight: 74511.37

Authors

Kuo, A.,Gulbis, J.M.,Antcliff, J.F.,Rahman, T.,Lowe, E.D.,Zimmer, J.,Cuthbertson, J.,Ashcroft, F.M.,Ezaki, T.,Doyle, D.A. (deposition date: 2003-05-01, release date: 2003-06-17, Last modification date: 2024-02-14)

Primary citation

Kuo, A.,Gulbis, J.M.,Antcliff, J.F.,Rahman, T.,Lowe, E.D.,Zimmer, J.,Cuthbertson, J.,Ashcroft, F.M.,Ezaki, T.,Doyle, D.A.
Crystal structure of the potassium channel KirBac1.1 in the closed state.
Science, 300:1922-1926, 2003

PubMed Abstract: The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.

PubMed: 12738871
DOI: 10.1126/science.1085028

Experimental method

X-RAY DIFFRACTION (3.65 Å)