1O42
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU81843.
Summary for 1O42
| Entry DOI | 10.2210/pdb1o42/pdb |
| Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-O-PHOSPHONOTYROSINAMIDE (3 entities in total) |
| Functional Keywords | sh2 domain fragment approach, signaling protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane: P12931 |
| Total number of polymer chains | 1 |
| Total formula weight | 12954.55 |
| Authors | Lange, G.,Loenze, P.,Liesum, A. (deposition date: 2003-06-15, release date: 2004-02-17, Last modification date: 2023-08-16) |
| Primary citation | Lange, G.,Lesuisse, D.,Deprez, P.,Schoot, B.,Loenze, P.,Benard, D.,Marquette, J.P.,Broto, P.,Sarubbi, E.,Mandine, E. Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46:5184-5195, 2003 Cited by PubMed: 14613321DOI: 10.1021/jm020970s PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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