1NQC
Crystal structures of Cathepsin S inhibitor complexes
Summary for 1NQC
Entry DOI | 10.2210/pdb1nqc/pdb |
Related | 1NPZ |
Descriptor | Cathepsin S, N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE (3 entities in total) |
Functional Keywords | antigen presentation, binding specificity, cysteine proteases, inhibitor complexes, structure-based design, structural plasticity, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P25774 |
Total number of polymer chains | 1 |
Total formula weight | 24476.53 |
Authors | Pauly, T.A.,Sulea, T.,Ammirati, M.,Sivaraman, J.,Danley, D.E.,Griffor, M.C.,Kamath, A.V.,Wang, I.K.,Laird, E.R.,Menard, R.,Cygler, M.,Rath, V.L. (deposition date: 2003-01-21, release date: 2003-04-15, Last modification date: 2023-08-16) |
Primary citation | Pauly, T.A.,Sulea, T.,Ammirati, M.,Sivaraman, J.,Danley, D.E.,Griffor, M.C.,Kamath, A.V.,Wang, I.K.,Laird, E.R.,Seddon, A.P.,Menard, R.,Cygler, M.,Rath, V.L. Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42:3203-3213, 2003 Cited by PubMed: 12641451DOI: 10.1021/bi027308i PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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