1MS8
Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)
Summary for 1MS8
Entry DOI | 10.2210/pdb1ms8/pdb |
Related | 1MR5 1MS0 1MS1 1MS3 1MS4 1MS5 1MS9 1MZ5 1MZ6 |
Descriptor | trans-sialidase, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID (3 entities in total) |
Functional Keywords | sialidase, trans-glycosylation, protein-carbohydrate interactions, beta-propeller, hydrolase |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 2 |
Total formula weight | 143361.03 |
Authors | Buschiazzo, A.,Amaya, M.F.,Cremona, M.L.,Frasch, A.C.,Alzari, P.M. (deposition date: 2002-09-19, release date: 2003-03-25, Last modification date: 2021-10-27) |
Primary citation | Buschiazzo, A.,Amaya, M.F.,Cremona, M.L.,Frasch, A.C.,Alzari, P.M. The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10:757-768, 2002 Cited by PubMed: 12419220DOI: 10.1016/S1097-2765(02)00680-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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